சர்க்கரையில் வளரும் கேன்சர் செல்கள்

ஒருவருக்கு புற்றுநோய் இருப்பதை கண்டறியும் எம்ஆர்ஐ சோதனை செய்யும் போது, அதனை எளிதாக அறிய சர்க்கரை உதவும் என்று விஞ்ஞானிகள் கண்டு பிடித்துள்ளனர்.
லண்டன் கிங்ஸ் கல்லூரி, லண்டன் பல்கலைக்கழக ஆராய்ச்சியாளர்கள் இணைந்து, இதனை கண்டறிந்துள்ளனர். ஸ்கேன்களில் சோதனையின் போது வெளிச்சத்திற்ககாக கட்டிகள் மேலே சர்க்கரை பயன்படுத்தி புற்றுநோய் கண்டறியும் புதிய மற்றும் இலகுவான உத்தியை உருவாக்கியுள்ளனர். இதன் காரணம் மனிதனின் மற்ற செல்களை விட புற்றுநோய் செல்கள் தங்களது வளர்ச்சிக்கு அதிகமான சர்க்கரையை ஈர்த்துக் கொள்கின்றன என்பதுதான்.


எம்ஆர்ஐ ஸ்கேன் பயன்படுத்துவதற்கு முன்பே மனிதனின் உடலுக்குள் குளுக்கோஸ் செலுத்தப்படும், புற்றுநோய் செல்கள் அதிகமாக ஈர்த்துக் கொள்ளவதால் எம்ஆர்ஐ ஸ்கேன்களில் எளிதாக அடையாளம் காணலாம்.

புற்றுநோயின் செல்களை எளிதாக காண்பதற்கு இந்த புது நுட்பத்தை ‘ குளுக்கோஸ் இரசாயன பரிமாற்றம் பூரித பரிமாற்றம்(glucocest) ‘என்று பெயரிட்டுள்ளனர்.


எதிர்காலத்தில், நோயாளிகள் சிறப்பு மருத்துவ மையங்களை காட்டிலும் உள்ளூர் மருத்துவ மையங்களிலும் ஆற்றல்மிக்க ஸ்கேன் செய்யப்பட முடியும் என்று தெரிய வருகிறது.

Research shows glucose feeds cancer cells - can you do something about this?

Be clear - there are more than six research studies in the last few years which show that
1. People with the highest levels of blood glucose develop more cancers;

and,

2. People with cancer, who also have the highest blood levels of glucose, survive least.

One study was specifically for brain tumours. The research makes a mockery of NHS booklets that encourage a diet of cheeseburgers, sticky buns, milkshakes and sweet, sugary tea during chemotherapy. In fact the latest recommendations from Memorial Sloan-Kettering and MD Anderson in the USA are to eat healthily, and not pile into rubbish foods with empty calories.

Cancer cells need supplies of common glucose to grow

The breakdown of glucose to provide energy is called glycolysis. In a healthy cell, glucose is converted in the cellular cytoplasm in a multi-step process to pyruvate, which passes into the mitochondria (or power stations) to be ´burned´ in another multi-step process in the presence of oxygen. This process involves electron transfer in the mitochondrial membrane.

Healthy cells can use other forms of ´food´ like fats, as precursors.

Cancer cells cannot. They can only derive energy from glycolysis in the cytoplasm. The mitochondria have been ´knocked out´ of the process. A further complication is that under normal circumstances, the mitochondria regulate the cell - if something is flawed in the cell, the mitochondria can cause cell death. This mechanism is also lost in cancer. Even if oxygen is restored to the cells, there is little evidence that mitochondria can switch back on again.

Cancer cells need glucose. In fact they can make it. Not enough to grow, but enough to survive. They need you to feed them glucose to grow.

They make their energy from the first step of the normal process - but in the absence of oxygen - it is called anaerobic glycolysis.

The waste product from this process of anaerobic glycolysis is a form of lactic acid, which can only be broken down by the liver. So the lactic acid passes from the cancer cell to the liver where it is broken down. And the waste product of that process is ............. glucose! This then passes back round the body to feed the cancer cell. This cycle can take over the body in cancer.

Of course as cancers grow they need more and more glucose. But don´t worry. The NHS dieticians will tell you that if you are having chemotherapy, you should eat lots of calories - from fatty foods, dairy and glucose. This is to protect the seven per cent of patients that experience serious weight loss (cachexia) due to the drugs - and we couldn´t possibly have drugs killing people, could we? Sadly, in the defence of NHS dieticians, they are so overworked they only get time to see the people who are seriously ill from cachexia. The majority of patients have little or no problems, but still get the booklet to read!

Eat Glucose at your peril

At CANCERactive we say, if you have cancer, eat glucose and sugary foods at your peril. And there is plenty of research from places such as Harvard Medical School to support our view. In 2012 Cancer Watch covered research that high fructose corn syrup could be even worse than common sugar - you´ll find it abundantly in fizzy soft drinks. There is some evidence that if you starve cancer cells of glucose and HFCS they can sometimes use glutamine from your cells as a reserve fuel supply, but glucose is the main food source.

So, the most important rule in fighting cancer is: Cut out common sugar, chocolate, cakes, biscuits, ice cream, fizzy soft drinks, Ribena, and processed and packaged food as a start! And be warned: ´Healthy honey´ is 50 per cent glucose and fructose!

Can you starve cancer of glucose?

You should be trying to starve that cancer of glucose. Indeed, there is research on ´fasting and cancer´, which induces a process called ketosis. A cancer cell needs glucose but, after fasting, little is present so it is compromised. Healthy cells can burn fats (ketosis) but cancer cells cannot. So varying results have shown anything from the death of the cancer cell, to a restriction in tumour growth.

The next step up (because, according to research, 70 per cent of patients would not want to fast) is to add in quality protein (fresh fish and organic chicken) and good fats (like extra virgin olive oil, fish oils, flaxseed oil and coconut oil). This is called the Ketogenic Diet and research is being conducted for its use with brain tumours. And early results look promising.

Then there is the issue of cachexia. Boston Biology Professor Seyfried confirms that fish oils can minimize the risk of cachexia, as was shown with lung cancer in research in 2012 (see Cancer Watch).

A far more controversial approach follows the beliefs of an American Doctor called Joseph Gold, and a number of Russian experts, who have all recommended that cancer patients take Hydrazine Sulphate as this blocks the glucose - lactic acid - glucose cycle. This route has caused heated debate. Some people absolutely ´pan´ the use of Hydrazine Sulphate; while others get excited, claiming there is research. The fact is the research was from Russia and had limitations.

So there are limited clinical trials on this cheap ´alternative cancer treatment´; and the claimed benefits have been ridiculed; plus it is nigh on impossible to obtain it!! We pass the information on; what you do with it is your business.

Can you turn the mitochondria back on?

Another inexpensive ´alternative treatment´ is Sodium Dichloroacetate, the sodium salt of dichloroacetate or DCA, which has been the subject of limited research studies at the University of Alberta Medical School. Again, this compound has its critics but there may be more to it. Clinical Trials have started. Researchers believe it can cause cancer cell death, by reactivating the mitochondria in cells currently using glycolysis as their energy production system. Thus the mitochondria ´wake up´ and start the cancer cell suicide process. DCA has huge potential.

Glucose control is in your own hands!

The fact is, you have your blood sugar levels in your own hands. You can cut glucose and HFCS from your diet and you can take exercise (30 minutes a day) as exercise can help control blood glucose levels. You could even fast. Memorial Sloan-Kettering wrote to us after we published our article explaining that they are seriously considering using fasting as an anti-cancer complementary therapy!r Perhaps it is no co-incidence the American Cancer Society are saying there is ´overwhelming´ research that diet and exercise can increase survival times.

 

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